Luc Brunsveld

This paper designs molecular glues that stabilize the 14-3-3/C-RAF autoinhibited complex, showing selectivity and functional effects in biophysical and cell assays.

This paper develops a molecular glue-based PROTAC (MGPROTACs) to ubiquitinate the 14-3-3/Estrogen Receptor complex, demonstrating cooperative complex formation and selective ubiquitination through linker design.

This study shows that 14-3-3ζ binding to phosphorylated Tau reduces its association with microtubules and inhibits aggregation and condensation.

This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

The paper identifies crosstalk between ERRalpha and PPARalpha transcription factors, showing ERRalpha can act as both a repressor and activator of PPARalpha-mediated gene expression.

This paper describes a DNA-based synthetic apoptosome that demonstrates proximity-driven enzymatic activity and provides insights into caspase-9 regulation.