Author

Linda J. Olson

Medical College of WisconsinORCID 0000-0001-5910-7281Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Aashish ManglikiD· 1 shared Alexa De La Sancha· 1 shared Andy ChevignéiD· 1 shared Brian F. VolkmaniD· 1 shared Christian BillesboelleiD· 1 shared Emmanuel Duarte BarbosaiD· 1 shared Francis C. PetersoniD· 1 shared Heather E. CliftiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Aashish ManglikORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 11, 2026

Atypical GPCR Activation Resolved by Nanobody Engineering

Roman R. Schlimgen, Shawn E. Jenjak, Alexa De La Sancha…·Brian F. Volkman

This study reveals an unconventional activation mechanism of the atypical GPCR ACKR3 using engineered nanobodies and cryo-EM, showing that extracellular pocket volume changes, not microswitch conformational shifts, drive receptor activity.

DOI 10.64898/2026.01.10.698836

humancryo-EM

𝕏 PostBluesky

Pharmacology & ToxicologyACS Chemical NeurosciencePeer-reviewedNov 1, 2024

Structural Insights into Dopamine Receptor-Ligand Interactions: From Agonists to Antagonists

Emmanuel Duarte Barbosa, Yuanyuan Ma, Heather E. Clift…·Wei Liu

This study investigates dopamine receptor-ligand interactions using molecular modeling, revealing binding modes and stability of agonists and antagonists at D1R and D5R.

6 citations

mechanistic / dynamical modeldrug response / drug discovery

𝕏 PostBluesky