Markus Schröder

The paper develops RaPID-seq to study homology search during HDR and finds that DSB proximity determines template candidacy, with distant sequences not efficiently searched despite sequence identity.

The paper improves the activity of compact RNA-guided nucleases in mammalian cells through directed evolution, resulting in variants with higher editing efficiency and reduced off-target effects.

This study identifies DCLRE1A as a key factor in CAG repeat contraction following Cas12a-induced DNA breaks and demonstrates its role in enhancing repeat shortening through interactions with repair proteins.

The paper develops scOUT-seq to profile DNA repair outcomes in single cells and finds that repair outcomes vary significantly across cell types and subtypes.

The paper maps genetic interactions of DDR genes using CRISPRi screening, identifies key interactions with therapeutic potential, and provides insights into genome maintenance mechanisms.

The paper identifies CCAR1 as a splicing fidelity factor that regulates alternative splicing of FANCA and other genes, impacting DNA repair processes.

This paper shows that epitope-engineered human hematopoietic stem cells are protected from CD123-targeted immunotherapy while maintaining functionality, offering a strategy for tumor-selective therapy.

This study shows that inhibiting NMD reduces tumorigenicity in HT1080 fibrosarcoma cells by lowering MMP9 expression, suggesting NMD inhibition as a potential cancer therapy.

The paper identifies ATF4 as a key regulator of fetal globin re-expression in response to reduced β-globin, providing mechanistic insight into stress-induced globin compensation.