Pilar de la Puente

This study develops patient-derived tumor-immune models that mimic hypoxia and extracellular matrix changes, revealing TGF-β targeting opportunities to improve immune infiltration in cold tumors.

This paper develops a tumor-on-a-chip model to study ovarian cancer drug resistance by mimicking tumor-stroma interactions and compartmentalized microenvironment.

This study reprograms normal uterine fibroblasts into ovarian cancer-associated fibroblasts using ovarian tumor-derived conditioned media, demonstrating enhanced tumor progression and drug resistance.