Galadriel A. Hovel-Miner

This study compares the cytotoxic effects of fexinidazole, nifurtimox, and benznidazole on Trypanosoma brucei, showing fexinidazole uniquely inhibits DNA synthesis while the others induce DNA damage.

The paper creates a T. brucei ORFeome and Gain-of-Function library to identify genes promoting survival during melarsoprol treatment, finding 57 genes including a known drug target and novel genes related to resistance mechanisms.

The paper uses a T. brucei ORFeome to create a Gain-of-Function library and identifies novel genes linked to melarsoprol resistance.