Author

Victor Tkachev

Boston Children's HospitalORCID 0000-0001-6011-0576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Organism:non-human primate· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Leslie S. KeaniD· 4 shared Francesca Alvarez CalderoniD· 3 shared Lorenzo S CagniniD· 3 shared Marlana Winschel· 3 shared Ulrike GerdemanniD· 3 shared Elisa Rojas PalatoiD· 2 shared James KaminskiiD· 2 shared Jennifer F. LaneiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Leslie S. KeanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologyBlood Immunology & Cellular TherapyPeer-reviewedApr 20, 2026

Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies

Holly Wobma, Francesca Alvarez Calderon, Jiayi Dong…·Leslie S. Kean

This study edits Cyclophilin A's C-terminus using CRISPR/Cas9 to create cell therapies resistant to cyclosporine and voclosporin, preserving function in immune suppression settings.

DOI 10.1016/j.bict.2026.100054

mousegenetic perturbation / CRISPR

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ImmunologybioRxivPreprintSep 17, 2025

PTPN2-KO CAR-T Cells Demonstrate Enhanced Effector Function, CNS Infiltration, and Toxicity in a Non-Human Primate CAR-T Model

Francesca Alvarez Calderon, Ryan A. Fleming, Marlana Winschel…·Ulrike Gerdemann

DOI 10.1101/2025.09.17.676426

non-human primatebulk RNA-seq

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ImmunologyBloodPeer-reviewedApr 1, 2024

B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients

James Kaminski, Ryan A. Fleming, Francesca Alvarez Calderon…·Ulrike Gerdemann

The paper identifies a novel mechanism where CAR-T cell therapy activates CD8+ cytotoxic bystander T cells in non-human primates and patients, showing they can kill leukemic cells independently of TCR.

29 citationstop 3%

non-human primatehuman

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NeuroscienceNaturePeer-reviewedSep 30, 2020

Innovations in Primate Interneuron Repertoire

Fenna M. Krienen, Melissa Goldman, Qiangge Zhang…·Steven A. McCarroll

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.

381 citationstop 1%

humanmouse

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