Dieter Niederacher

This study develops a bipyrimidineamide-based α-helix mimetic compound, VWK603, which effectively targets MDM2 in TNBC cells with lower toxicity than Nutlin-3a.

This study shows that inhibiting lysosomal acid lipase (LIPA) reduces breast cancer stemness and sensitizes triple-negative breast cancer (TNBC) cells to chemotherapy, suggesting LIPA as a novel therapeutic target.

ZeptoCTC is a single-cell protein analysis workflow that uses RPPA to measure protein expression and activation in CTCs, showing higher pAkt levels in mutated CTCs compared to wild-type.