Joachim Heberle

This paper resolves the mechanism of covalent bond formation in a LOV photoreceptor using time-resolved crystallography and spectroscopy, revealing a water-mediated proton transfer that accelerates the reaction by fourteen orders of magnitude.

This study identifies a low-barrier hydrogen bond as the key to long-range radical transfer in metal-free ribonucleotide reductase.

The paper introduces a separate-scan AFM system integrated with BI-sSNOM to enable faster imaging of biomolecules in aqueous solutions.

This paper reports a method to capture the blue-light activated state of the Phot-LOV1 domain using time-resolved serial synchrotron crystallography and provides structural insights into its activation cascade.

This paper introduces SIP-nanoFTIR to quantify single-cell metabolism and observe growth-dependent spectral features in bacteria.