Author

Shannon Zhuang

German Center for Neurodegenerative DiseasesORCID 0000-0001-6416-5064Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Organism:virus· 1

Frequent Co-Authors

Alain Ibáñez de OpakuaiD· 1 shared Benjamin L. WoloziniD· 1 shared Carter T. ButtsiD· 1 shared Debdeep ChatterjeeiD· 1 shared Elizabeth M. DiessneriD· 1 shared Gemma R. TakahashiiD· 1 shared Jeffrey A. PurslowiD· 1 shared Markus ZweckstetteriD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Alain Ibáñez de OpakuaORCID

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2 papers

Recent·Most cited

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedDec 18, 2024

GSK3β phosphorylation catalyzes the aggregation of Tau into Alzheimer's disease-like amyloid strain

Pijush Chakraborty, Alain Ibáñez de Opakua, Jeffrey A. Purslow…·Markus Zweckstetter

This study shows GSK3β phosphorylation drives tau aggregation into Alzheimer's-like amyloid strains through enhanced phase separation.

106 citationstop 1%

proteomicsexperimental assay

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Molecular BiologyBiochemistryPeer-reviewedSep 15, 2020

Sequence Characterization and Molecular Modeling of Clinically Relevant Variants of the SARS-CoV-2 Main Protease

Thomas J. Cross, Gemma R. Takahashi, Elizabeth M. Diessner…·Rachel W. Martin

The paper characterizes 79 clinically relevant SARS-CoV-2 main protease variants through sequence analysis, structure prediction, and molecular modeling, revealing patterns in viral evolution and active site flexibility.

46 citations

virusprotein structure

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