Author

Jeffrey A. Purslow

German Center for Neurodegenerative DiseasesORCID 0000-0001-8828-0809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alain Ibáñez de OpakuaiD· 1 shared Amy Hamilton AndreottiiD· 1 shared Benjamin L. WoloziniD· 1 shared D. Bruce Fulton· 1 shared David Yin-wei LiniD· 1 shared Debdeep ChatterjeeiD· 1 shared Julien RocheiD· 1 shared M. Paul GleesoniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Alain Ibáñez de OpakuaORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 17, 2026

BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.

Raji E. Joseph, Robert G. Britton, David Yin-wei Lin…·Amy Hamilton Andreotti

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

DOI 10.64898/2026.05.07.723540

humanexperimental assay

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedDec 18, 2024

GSK3β phosphorylation catalyzes the aggregation of Tau into Alzheimer's disease-like amyloid strain

Pijush Chakraborty, Alain Ibáñez de Opakua, Jeffrey A. Purslow…·Markus Zweckstetter

This study shows GSK3β phosphorylation drives tau aggregation into Alzheimer's-like amyloid strains through enhanced phase separation.

106 citationstop 1%

proteomicsexperimental assay

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