Mirco Dindo

This study shows that enzymes in biomolecular condensates enhance catalytic activity through crowding-induced conformational changes and enable increased mobility despite environmental viscosity.

The paper compares scRNA-seq and snRNA-seq in Praesagittifera naikaiensis, finding snRNA-seq better recovers neural transcripts and reduces symbiont reads.

This study investigates RNA condensates formed at acidic pH, showing they compartmentalize biomolecules, enhance reaction rates, and act as microreactors with catalytic activity, supporting the RNA world hypothesis.

This study develops and characterizes six nanobodies as potential therapeutics for PH1 by targeting misfolded AGT variants, showing high affinity and functional enhancement in cellular models.

This study engineers Oxalate decarboxylase to improve its activity and stability for medical applications in hyperoxaluria treatment.

This study shows enzymatic activity reduces viscosity in crowded environments, enhancing substrate diffusion by up to three-fold through disruption of non-covalent interactions.

The paper shows that non-consecutive TCA cycle enzymes MDH and ICD interact in droplets, enhancing ICD activity and affecting carbon-nitrogen metabolism in B. subtilis.