Iván Martínez-Valbuena

This study compares soluble α-synuclein species from MSA and LBD brains, finding differences in their seeding activity and size distribution.

The paper identifies a Lewy-MSA hybrid fold of α-synuclein in atypical MSA, linking distinct filament structures to neuronal versus oligodendroglial pathologies.

This study examines SNCA transcription in neurons with different -syn cytopathologies in LBD, finding preserved transcripts in non-Lewy body types and reduced in Lewy bodies.

The paper investigates molecular subtypes in PSP by analyzing tau seeding activity and identifies immune-related pathways associated with disease progression.

This study introduces a modified Real-Time Quaking-induced Conversion assay to assess alpha-synuclein seeding activity in multiple system atrophy, revealing heterogeneity in seeding behavior across brain regions.