Lydia R. Chambers

The paper defines how the CapP peptidase is activated by single-stranded DNA, leading to transcriptional activation of immune operons in response to DNA damage.

The paper identifies CapK and CapS proteins that regulate immune operon expression in response to DNA damage in bacteria.

This study characterizes the Bub bacterial ubiquitination-like pathway, revealing its unique biochemical mechanisms and structural similarities to eukaryotic ubiquitination.

This study identifies structural diversity and Ca2+-mediated oligomerization in bacterial ubiquitin-like proteins, suggesting a role in stress response.

This study shows bacteria have a complete ubiquitination pathway similar to eukaryotes, with structural and functional parallels to eukaryotic systems.