Author

Hao Li

Howard Hughes Medical InstituteORCID 0000-0001-6514-0352Unclaimed ORCID profile · follow to get notified of new preprints

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Hao Li16 papers · University of California, San Francisco

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Organism:yeast· 1

Frequent Co-Authors

Tom A. RapoportiD· 2 shared Haipeng GuaniD· 1 shared João A. PauloiD· 1 shared Steven P. GygiiD· 1 shared Zhejian JiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersBiochemistry

Tom A. RapoportORCID

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2 papers

Recent·Most cited

BiochemistryScientific ReportsPeer-reviewedMar 7, 2026

The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation

Hao Li, Haipeng Guan, Tom A. Rapoport

The paper shows that Otu1 removes ubiquitin chains from substrates to enable their transfer from Cdc48 ATPase to proteasome for degradation.

DOI 10.1038/s41598-026-42811-6

experimental assayprotein folding & dynamics

𝕏 PostBluesky

BiochemistryMolecular CellPeer-reviewedFeb 23, 2024

Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation

Hao Li, Zhejian Ji, João A. Paulo…·Tom A. Rapoport

The paper demonstrates bidirectional substrate shuttling between the 26S proteasome and Cdc48 ATPase in yeast, showing how this process facilitates protein degradation.

27 citations

yeastexperimental assay

𝕏 PostBluesky