Kamalika Mukherjee

The paper identifies HuR as a miRNA sensor that uncouples miRNAs from Ago2 and promotes their storage on lipid droplets to buffer miRNA activity in mammalian cells.

The paper shows that activated macrophages export miRNAs cooperatively, with miR-122 enhancing the export of miR-146a via HuR-mediated endosomal entry.

The paper shows that HuD replaces HuR in regulating miRNA export during neuronal differentiation, promoting differentiation by altering miRNA activity.

This paper isolates and quantifies mRNAs from subcellular phase-separated structures in brain cells to study how amyloid proteins affect mRNA dynamics in neurons and glial cells.

The paper shows that specific miRNAs, including miR-122, are reversibly shuttled to mitochondria in stressed hepatic cells, where they regulate apoptosis-related gene expression and cytosolic miRNA levels.

This study shows amyloid beta oligomers enhance Ago2 phase separation to RNA processing bodies by promoting miRNA-mRNA targeting, while HuR counteracts this effect.

This paper identifies Syntaxin5's role in miRNA export and pathogen clearance by showing its RNA-binding and SNARE domain functions in macrophages.

The paper uses single molecule imaging to study HIV-1 promoter pausing and finds that stochastic pausing leads to transcriptional bursting in latent cells.

The paper shows that GW182 proteins restrict the export of used miRNAs via extracellular vesicles in cancer cells, independent of HuR, and that this process is linked to miRNA turnover and cellular senescence.