Author

Zhiwei Ang

Children's Hospital of PhiladelphiaORCID 0000-0001-6583-4733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Andrei Thomas‐TikhonenkoiD· 3 shared Annette CastroiD· 3 shared Katharina E. HayeriD· 3 shared Priyanka D. SehgaliD· 3 shared Jamie B. SpangleriD· 2 shared Justyn Fine· 2 shared Manuel Torres-DiziD· 2 shared Mathieu Quesnel-VallièresiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

Andrei Thomas‐TikhonenkoORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJan 26, 2026

The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target

Zhiwei Ang, Annette Castro, Luca Paruzzo…·Andrei Thomas‐Tikhonenko

The paper identifies P2RX5 as a new B-cell surface marker and multi-lineage immunotherapy target, showing its expression in B-cell malignancies and T-cell leukemia, and demonstrating the efficacy of P2RX5-directed therapies.

DOI 10.64898/2026.01.14.698748

humanbulk RNA-seq

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Cancer BiologyCell ReportsPeer-reviewedAug 1, 2025

NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas

Priyanka D. Sehgal, Ammar S. Naqvi, Makenna Higgins…·Andrei Thomas‐Tikhonenko

The paper identifies a NRCAM proteoform with skipped microexons as a targetable surface antigen in pHGG and demonstrates its utility in immunotherapy.

6 citations

humanbulk RNA-seq

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Cancer BiologyCancer ResearchPeer-reviewedAug 2, 2024

An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia

Manuel Torres-Diz, Clara Reglero, Catherine D. Falkenstein…·Andrei Thomas‐Tikhonenko

The paper identifies an alternatively spliced NT5C2 isoform contributing to chemoresistance in B-ALL by enhancing nucleosidase activity and 6-MP resistance.

13 citations

humanbulk RNA-seq

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