Hideyuki Saya

The paper introduces PiER, a DNA-based system for functional gene screening that records perturbation-response events without single-cell isolation, and demonstrates its use in identifying WNT-related shRNA candidates.

The paper identifies RNPS1 in the PSAP complex as a key factor controlling periodic pre-mRNA splicing during the cell cycle, with its protein levels regulated by the ubiquitin-proteasome pathway.

This study identifies six drugs that enhance autophagy by promoting lysosomal clustering, which facilitates the degradation of protein aggregates associated with Parkinson's disease.

The paper identifies kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore and shows its role in pigment cell specification.