B. Vijayalakshmi Ayyar

The paper compares GII.4 norovirus variants to determine if clustering and entry mechanisms are conserved, finding clustering enhances entry and is mediated by specific residues and lipid rafts.

This study identifies host restriction factors limiting HuNoV passaging in HIEs and demonstrates that TAK-779 enhances viral replication and enables continuous passaging.

This paper shows that 2'-fucosyllactose inhibits replication of a dominant human norovirus strain in intestinal enteroids from adult and pediatric donors.

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

This study shows that BA-dependent human norovirus strains require S1PR2 for infection, while BA-independent strains do not, suggesting S1PR2 as a potential therapeutic target.