Alexander Edward Dela Cruz Drilon

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

This study shows that type II TKIs cabozantinib and merestinib, and type I FLT3 inhibitor gilteritinib, inhibit ROS1 L2086F mutant kinase, overcoming resistance to type I TKIs in ROS1 fusion-positive cancers.