Author

Jacob A. Boyer

Ludwig Cancer ResearchORCID 0009-0003-6695-1423Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jacob A. Boyer2 papers · Ludwig Cancer Research

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander Edward Dela Cruz DriloniD· 1 shared Anita DonliciD· 1 shared Clifford P. BrangwynneiD· 1 shared Corina AmoriD· 1 shared Douglas Warner· 1 shared Elisa de StanchinaiD· 1 shared Ezra Y. RoseniD· 1 shared Fresia G. ParejaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Alexander Edward Dela Cruz DrilonORCID

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2 papers

Recent·Most cited

BiochemistryACS Chemical BiologyPeer-reviewedMar 6, 2026

Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicity

Xuemeng Sun, Anita Donlic, Jacob A. Boyer…·Ralph E. Kleiner

This study investigates the metabolism of epigenetic ribonucleosides in human cells, revealing cytotoxic effects and mechanisms of RNA misincorporation and nucleolar stress.

1 citation

humanbulk RNA-seq

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Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 21, 2025

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

Jacob A. Boyer, Ezra Y. Rosen, Malvika Sharma…·Neal X. Rosen

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

16 citationstop 1%

humanproteomics

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