Author

Andrea R. Beccari

Dompé (Italy)ORCID 0000-0001-6830-2695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea ZalianiiD· 2 shared Carmine TalaricoiD· 2 shared Daniela IaconisiD· 2 shared Enzo TramontanoiD· 2 shared Francesca EspositoiD· 2 shared Jeanette ReinshageniD· 2 shared Maria KuzikoviD· 2 shared Markus Wolf· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Andrea ZalianiORCID

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3 papers

Recent·Most cited

Molecular BiologyCommunications BiologyPeer-reviewedOct 19, 2023

Structure of human TRPM8 channel.

Sergiy S. Palchevskyy, Mariusz Czarnocki‐Cieciura, Giulio Vistoli…·Carmine Talarico

The paper presents a cryo-EM structure of the human TRPM8 channel in the closed state and analyzes its ligand interactions and conformational states.

46 citationstop 1%

humanprotein structure

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Molecular BiologybioRxivPreprintOct 11, 2023

Resolving the pharmacological redox-sensitivity of SARS-CoV-2 PLpro in drug repurposing screening enabled identification of the competitive GRL-0617 binding site inhibitor CPI-169

Maria Kuzikov, Stefano Morasso, Jeanette Reinshagen…·Andrea Zaliani

The paper identifies CPI-169 as a competitive inhibitor of SARS-CoV-2 PLpro that targets the same binding site as GRL-0617, through a drug repurposing screening approach that accounts for redox-sensitivity.

2 citations

humanexperimental assay

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Molecular BiologyACS Pharmacology & Translational SciencePeer-reviewedMar 11, 2021

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen…·Andrea Zaliani

The paper identifies 62 new inhibitors of SARS-CoV-2 3CL-Pro through a compound repurposing screen and validates their activity using X-ray crystallography.

159 citationstop 1%

experimental assaydrug response / drug discovery

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