D. Alex Crowder

The paper identifies signal attrition in XL-MS as the main cause of poor interactome sampling, not low crosslink yield, and highlights issues with signal splitting and database search tools.

The paper introduces a novel crosslinking method using click chemistry to enhance XL-MS sampling depth and detect more protein-protein interactions.

The paper demonstrates how data-independent acquisition methods can automate hydrogen/deuterium exchange mass spectrometry measurements with improved precision and throughput.

This paper develops an HX-MS2 workflow using DIA methods for automated HX data analysis, improving validation and throughput in proteomics.

The paper introduces an upgraded CRIMP tool for detecting crosslinked peptides in XL-MS data, showing improved sensitivity and resolution of protein interactions.