Xiao‐Dong Su

This paper introduces TCRDiff, a conditional diffusion model for generating antigen-specific TCR sequences, validated through in vitro assays.

The paper identifies short anchoring elements (AEs) that dominate DNA-protein interactions for four TFs and develops AEEscape to analyze their binding energy landscapes.

This study uses KaScape to identify YsiA DNA binding sites in B. subtilis, finding that half-sites suffice for binding and revealing new minor sequences.

The paper models the structure of Omicron's RBD and human ACE2, showing mutations enhance binding strength through hydrogen bonding and increased buried surface area.