Cell BiologyiSciencePeer-reviewed
Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes
Xi Zhang, Tanuza Das, Tiffany F. Chao…·Lindsey R. Hayes
This study shows that multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus, forming high molecular weight RNPs, but pure GU-repeats impair TDP-43 function.