Roberto Sitia

The paper shows KDELR1 and KDELR3 regulate AGR2 production oppositely, revealing a novel regulatory circuit involving ERp44-KDELR3 interactions.

This study shows that IRE1α requires multiple dimers to undergo cross-phosphorylation and activate its RNase activity during ER stress.

The paper shows the UPR transitions from pro-survival to pro-death when ER expansion is excessive, using HeLa cells and genetic manipulations.