Wolfram Klapper

TCRanalyzer provides a user-friendly tool for analyzing TCR diversity, clonal expansion, and antigen specificity across tumor datasets.

This study presents the first comprehensive mutational and transcriptional analysis of B-cell precursor lymphoblastic lymphoma (BCP-LBL), revealing molecular similarities to BCP-ALL but with distinct mutation patterns in epigenetic modifiers.

This study identifies MDM4 as a critical target of 1q gain in TP53wt Burkitt lymphoma, showing its role in evading cell cycle arrest and highlighting its therapeutic potential.

ACEseq estimates allele-specific copy numbers, tumor purity, ploidy, and homologous recombination deficiency scores from tumor whole-genome sequencing by combining GC-bias correction, replication-timing correction, and structural variant breakpoints.