Viji Shridhar

This paper identifies nuclear cathepsin L as a regulator of replication stress in ovarian cancer, showing that its activation creates a therapeutic vulnerability through replication machinery remodeling and DNA repair inhibition.

This study identifies nuclear cathepsin L (nCTSL) as a biomarker for PARP inhibitor sensitivity in ovarian cancer and shows that combining clofarabine with PARP inhibitors enhances therapeutic response.