Daria Van Tyne

This study identifies anti-phage defense systems in VREfm genomes and finds limited associations between specific systems and phage resistance, with one candidate gene reducing susceptibility.

This study examines the transcriptomic changes in Pseudomonas aeruginosa isolates before and after Imi/Rel treatment, finding diverse gene expression responses across patients.

This study evaluates phage activity against E. faecalis isolates from infective endocarditis, finding that 83% of isolates were susceptible to at least one phage, and phage cocktails or combinations with antibiotics improved bacterial killing and survival in a model organism.

This study shows that inhibiting SagA, a peptidoglycan hydrolase, increases vancomycin susceptibility in VREfm through both genetic and pharmacological approaches.

This study compares high-depth whole genome sequencing of pooled (p-seq) and individual colonies (c5-seq) from blood culture plates to understand evolutionary dynamics in MRSA bacteremia, finding that c5-seq is more practical for tracking within-host evolution.

This study tracks genomic changes in Pseudomonas aeruginosa during antimicrobial treatment using single-isolate and metagenomic sequencing, revealing resistance mutations and population diversity.

This study identifies the Fsr quorum sensing system in Enterococcus faecalis as a negative regulator of biofilm growth and inflammation in infective endocarditis.

This study examines allele-specific effects of Rifampin Resistance-Determining Region (RRDR) mutations in RpoB on E. faecium physiology and antibiotic resistance, revealing varied impacts on growth, susceptibility, and hospital survival.

This study identifies arginine as a key regulator of mucoidy in hypervirulent Klebsiella pneumoniae, showing it activates the rmpADC promoter and modulates capsular polysaccharide chain length, impacting immune evasion and in vivo fitness.

The paper identifies mutations in Pseudomonas aeruginosa that confer cross-resistance to multiple beta-lactam antibiotics during treatment with ceftazidime/avibactam.

This study tracks the evolution of ST131 E. coli over 15 years at a single hospital, identifying dominant subclades and genetic adaptations associated with ESBL production.

This study investigates how lytic bacteriophages interact with respiratory epithelial cells and their effects on cytokine secretion, highlighting the need to consider mammalian responses in phage therapy.

The paper identifies prophages in Burkholderia spp. genomes that show lytic activity against conspecific and heterospecific isolates, suggesting their potential for phage therapy.