Liguo Zhang

The paper identifies acidic transcription factors that position genomic regions near nuclear speckles through both transcription-dependent and independent mechanisms.

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

The paper examines genome organization in human cells relative to nuclear locales, finding that gene expression and replication timing correlate with different nuclear structures and that LADs and iLADs compete for lamina attachment.

The paper uses TSA-seq to map genomic regions near nucleoli and pericentric heterochromatin in human cell lines, revealing variable heterochromatin localization and complex nuclear organization.

The paper detects SARS-CoV-2 retrotransposition into host genomes via LINE1 in infected cells but not in transfected cells, using WGS and TagMap methods.

The paper introduces TSA-seq to identify decondensed large-scale chromatin regions (DLCDs) and shows their association with chromatin domain boundaries.

The paper introduces SPIN, a method to identify genome-wide nuclear spatial localization patterns by integrating nuclear compartment mapping and chromatin interaction data.

SARS-CoV-2 RNA can be reverse-transcribed by LINE-1 or HIV-1 reverse transcriptase, integrated into the human genome, and transcribed as chimeric viral-cellular RNAs.

The paper introduces TSA-Seq, a method to measure chromosomal distances to nuclear structures and reveals a spatial gradient in genome activity correlated with nuclear compartments.