Author

David Dingli

Mayo ClinicORCID 0000-0001-7477-3004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Evolutionary Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Benjamin WerneriD· 2 shared Arne Traulsen· 1 shared Iftikhar AhmediD· 1 shared Jorge M. PachecoiD· 1 shared Laura Hindersin· 1 shared Nathaniel V. Mon PèreiD· 1 shared Tom LenaertsiD· 1 shared Weini HuangiD· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 9 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Benjamin WernerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 27, 2023

Clonal fitness decline in somatic differentiation hierarchies

Iftikhar Ahmed, David Dingli, Weini Huang, Benjamin Werner

The paper shows clonal fitness declines over time in somatic differentiation hierarchies, observable in human haematopoiesis and CLL, with a 1/time relationship and equilibrium fitness.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

Systems BiologyiSciencePeer-reviewedMar 20, 2021

Multistage feedback driven compartmental dynamics of hematopoiesis

Nathaniel V. Mon Père, Tom Lenaerts, Jorge M. Pacheco, David Dingli

This study models hematopoiesis as a compartmental system with feedback to understand how it responds to perturbations and identifies conditions for stable responses.

5 citations

humanbulk RNA-seq

𝕏 PostBluesky

Evolutionary BiologyBiology DirectPeer-reviewedAug 23, 2016

Should tissue structure suppress or amplify selection to minimize cancer risk?

Laura Hindersin, Benjamin Werner, David Dingli, Arne Traulsen

The paper examines whether tissue structure suppresses or amplifies selection to minimize cancer risk, finding that the distribution of mutant fitness effects determines the optimal tissue architecture.

DOI 10.1186/s13062-016-0140-7

statistical modelchromatin & epigenetic regulation

𝕏 PostBluesky