Joel P. Mackay

This study presents a multi-omic atlas of the siphonophore Physalia utriculus, revealing the regulatory mechanisms of colonial division of labour and the molecular basis of venom activity.

This study identifies ZNF512B as a spindle-associated protein that regulates metaphase exit and stem cell differentiation, independent of its zinc finger domains and NuRD complex interaction.

This study investigates BRD4's nucleosomal binding affinity and shows that histone acetylation modestly enhances this interaction, with little dependence on acetylation pattern.

This study reports the high-resolution cryo-EM structure of native human nucleosomes from HEK293 cells and provides mass spectrometry analysis of histone modifications.

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

This study investigates how DNA partitioning affects the phase behavior and dynamics of FUS condensates, revealing its role in modulating liquid-to-solid transitions and microstructure over time.

This study identifies ZNF512B as a repressor of gene expression that interacts with the NuRD complex via a conserved motif and can cause chromatin aggregation independently of NuRD.

This study identifies a phospho-regulated interaction between Dyn1xA and Endophilin A1 via a unique C-terminal extension, essential for ultrafast endocytosis.

This study identifies HMG20A as a key regulator of head and heart development by modulating transcription programs in neural crest cells and cardiomyocytes through its association with the H2A.Z/PWWP2A/NuRD complex.

The paper shows RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling by competing with nucleosome substrates, suggesting an evolutionary conserved mechanism.