Cancer BiologyCell Death and DiseasePeer-reviewed
Inducible mucosa-like differentiation of head and neck cancer cells drives the epigenetically determined loss of cell malignancy
Felix Oppel, Sarah Gendreizig, Laura Martínez-Ruiz…·Holger H. Sudhoff
This study shows that HNSCC cells can differentiate into non-malignant cells, losing their tumor-initiating potential and expressing KRT17, suggesting differentiation as a therapeutic target.
10 citations