Christopher A. Francis

This study uses machine learning to predict symbiotic lifestyles in microbial genomes, identifying 15-23% of uncultivated microbes as potential symbionts and creating a new catalog of symbiont genomes.

The paper identifies and characterizes Borgs and mini-Borgs in Methanoperedens archaea, revealing their evolutionary origins and genomic relationships.

The paper reports the crystal structure of 3-Hydroxypropionyl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus, revealing its subdomain organization and substrate-binding state.

The paper determines ambient temperature structures of the bifunctional Nmar_1308 enzyme from Nitrosopumilus maritimus, revealing new conformational dynamics relevant to synthetic biology.

The paper presents the crystal structure of Nmar_0206 from Nitrosopumilus maritimus, revealing a conserved interdomain linker loop that influences homodimer stability and contributes to the enzyme's energy efficiency in the 3HP/4HB cycle.