Hasan DeMi̇rci̇

This paper determines two X-ray crystal structures of a thermophilic lipase, showing that Pro367 ring puckering is associated with calcium binding and conformational selection.

This study presents X-ray structures of detemir in hexameric and dodecameric forms, revealing structural dynamics and identifying key residues involved in conformational changes and stability.

The paper reports the crystal structure of 3-Hydroxypropionyl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus, revealing its subdomain organization and substrate-binding state.

This study presents high-resolution crystal structures of two HSA dimerization patterns and analyzes electrostatic interactions and dipyridamole binding, showing their potential for drug delivery applications.

This study investigates how water and anion coordination affect insulin's structure and stability across a pH range, revealing pH-dependent electrostatic effects on protein dynamics and stabilization.

The paper presents the first dimeric ECR structure from Mesorhizobium metallidurans, revealing structural differences that may impact catalytic activity compared to tetrameric ECRs.

This study identifies the N-terminal order-disorder transition as critical for IscU's metamorphic behavior and shows it can be modulated by a peptide mimic.

The paper determines ambient temperature structures of the bifunctional Nmar_1308 enzyme from Nitrosopumilus maritimus, revealing new conformational dynamics relevant to synthetic biology.

This study reports the structure of the dimeric Keap1 Kelch domain at ambient temperature and identifies a novel compound, CNN, as a potential lead for Keap1 inhibition.

This study produces and purifies soluble recombinant HER2-TKD for structural studies and drug screening.

This paper describes the expression, purification, and crystallization of recombinant human ABL-1 kinase for structural analysis and drug screening in CML.

This study presents the crystal structure of FKBP1A at 1.05 Å resolution and performs docking studies to explore potential drug repurposing opportunities.

This study presents the crystal structure of human SOD1 and analyzes its structural dynamics and interactions with potential drug candidates for ALS treatment.

The paper uses X-ray crystallography and hydrogen-deuterium exchange to study insulin analog dynamics, showing faster deuterium exchange and structural insights into modified insulin monomers.

This study presents near-physiological structures of the Fc fragment from a biosimilar VEGF-Trap and shows structural plasticity through molecular dynamics simulations.

The paper presents the structure of TRAF6 N-terminal domain at 2.6 Å resolution, providing insights into its domain organization and zinc-binding, which are critical for its function and therapeutic targeting.

The paper determines the crystal structure of Vibrio cholerae (6-4) photolyase, revealing interactions with three cofactors and a potential DNA binding region.

This study demonstrates a high-throughput drug screening protocol using serial femtosecond X-ray crystallography for SARS-CoV-2 main protease, achieving 120 images/second with a new detector.