Daniel Krappmann

The paper develops a regression framework to identify pan-cancer single-gene biomarkers of drug sensitivity in cell line screens, recovering known markers and identifying new ones for ERK/MAPK inhibitors.

The paper assesses molecular EMT signatures in cancer cell lines to identify drug susceptibilities, showing EMT can predict responses to HSP90 inhibitors and enhance drug sensitivity through TGF-β stimulation.

The paper identifies a gut microbiome meta-interactome map showing how bacterial effectors modulate human immunity and are enriched in Crohn's disease.

The paper maps binary SARS-CoV-2 protein interactions with host proteins, identifying key processes like immune signaling and ubiquitination, and suggests therapeutic targets.