Cancer BiologyMolecular Therapy — Nucleic AcidsPeer-reviewed
Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3
Jeremy Hall, Zhuoran Zhang, S. Bhattacharya…·Marcin Kortylewski
This paper develops a PROTAC-based strategy to selectively degrade activated STAT3 in specific cell types, showing efficacy in reducing STAT3 levels and tumor growth in lymphoma models.