Luke Khoury

The paper uses single-cell proteomics and transcriptomics to reveal cell-type-specific functional coordination in PBMCs, showing protein covariation that reflects protein-protein interactions and pathway rewiring.

The paper introduces nPOP, a method for preparing single-cell samples for multiplexed proteomics, achieving accurate quantification of thousands of proteins per cell.

The paper identifies regulators of nucleocytoplasmic protein transport in macrophages using single-nucleus proteomics and validates findings through knockdown experiments.