Author

Siyi He

Centre Hospitalier de l’Université de MontréalORCID 0000-0001-7812-997XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anil Goud JeggaiD· 1 shared Azam Mohammadzadeh· 1 shared Camilla Ferreira WenceslauiD· 1 shared Daniel L. MeisteriD· 1 shared Daping FaniD· 1 shared Dong‐bao CheniD· 1 shared Elliott H Chen· 1 shared Gareth E. LimiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPathology

Anil Goud JeggaORCID

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2 papers

Recent·Most cited

Cancer BiologyCell Death and DiseasePeer-reviewedNov 10, 2025

A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: Repurposing drugs to disrupt 14-3-3 protein-BAD interactions

Siyi He, Daniel L. Meister, Samra Khan…·Gareth E. Lim

This paper uses a BRET-based high-throughput screen to identify FDA-approved drugs that disrupt 14-3-3{zeta}BAD interactions, showing potential for colorectal cancer treatment.

5 citations

humanexperimental assay

𝕏 PostBluesky

PathologybioRxivPreprintSep 2, 2025

Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations

Vi Nguyen, Irving Mao, Siyi He…·Wenbin Tan

The paper constructs a spatial transcriptomic atlas of capillary malformations, identifies EndMT and AJ disruption, and shows NR2F2 drives SMC phenotype acquisition in vascular lesions.

1 citation

humanspatial transcriptomics

𝕏 PostBluesky