Xavier Nicolas de Lamballerie

This study evaluates a human liver spheroid model for antiviral drug testing against BSL-3 HFVs, finding that some viruses replicate in the model and antiviral compounds show activity with dose variations.

The paper introduces Molecular Xenomonitoring (MX) to detect West Nile and Usutu viruses in mosquito populations, showing it can identify viral circulation before human cases.

The paper identifies a mutation in dengue virus genomes from the 2023-2024 French Caribbean epidemic that confers resistance to the anti-dengue compound mosnodenvir.

This study traces the evolutionary origins and molecular changes of a chikungunya virus outbreak in Thailand, identifying mutations linked to increased virulence and transmission.

The paper demonstrates an in vivo method to generate arboviruses from subgenomic DNA fragments, achieving 100% infection rate in mice with optimized electroporation parameters.

The paper generates and evaluates SARS-CoV-2 mutants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing in vitro and in vivo resistance and linking M49L mutation prevalence to Xocova(R) use.

The paper detects three porcine enteric viruses (PKoV, PAstV-1, and PSV) in Corsican pig farms using RT-qPCR and NGS, showing high prevalence and age-related differences.

The paper introduces a high-throughput tool to detect arboviruses in mosquitoes from Zika-endemic regions, showing its effectiveness in identifying circulating viruses.