Antoine Nougaırède

This study evaluates a human liver spheroid model for antiviral drug testing against BSL-3 HFVs, finding that some viruses replicate in the model and antiviral compounds show activity with dose variations.

The paper demonstrates an in vivo method to generate arboviruses from subgenomic DNA fragments, achieving 100% infection rate in mice with optimized electroporation parameters.

The paper generates and evaluates SARS-CoV-2 mutants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing in vitro and in vivo resistance and linking M49L mutation prevalence to Xocova(R) use.