Author

Lena Kobel

ETH ZurichORCID 0000-0001-7949-141XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Jacob E. CorniD· 2 shared Moritz F. SchlapanskyiD· 2 shared Simon C.C. LamiD· 2 shared Stephen P. JacksoniD· 2 shared Aldo S. BaderiD· 1 shared Alexandra Hart· 1 shared Andreas VillungeriD· 1 shared Chen Gang GohiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

Jacob E. CornORCID

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2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedOct 9, 2025

WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2

Jordan Wilson, Jiayi Zhu, Vanesa Vinciauskaite…·Stephen P. Jackson

This study shows WEE1 inhibitors work better with mRNA translation defects by activating GCN2, and suggests ways to reduce off-target effects.

3 citations

humanCRISPR screen

𝕏 PostBluesky

Cell BiologyNaturePeer-reviewedApr 9, 2025

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

John Fielden, Sebastian M. Siegner, Danielle N. Gallagher…·Jacob E. Corn

The paper maps genetic interactions of DDR genes using CRISPRi screening, identifies key interactions with therapeutic potential, and provides insights into genome maintenance mechanisms.

72 citationstop 1%

humangenetic perturbation / CRISPR

𝕏 PostBluesky