Yung-Chih Chen

The paper identifies Cpe1, an interbacterial cysteine protease toxin from E. coli, which inhibits bacterial growth by cleaving type II DNA topoisomerases GyrB and ParE, disrupting DNA replication and chromosome segregation.

The paper shows that phage resistance in Salmonella enterica leads to fitness loss when co-cultured with competitor bacteria due to LPS deficiency and increased susceptibility to T6SS.

This paper introduces a whole-cell screening platform to identify cell adhesion molecules targeting bacterial membrane proteins, successfully discovering functional CAMs that recognize three outer membrane proteins.