Ivo Gomperts Boneca

This study shows that Lgt is essential for membrane and flagellar integrity in H. pylori, and that revertant cells can overcome this stress through gene expression changes.

This study shows metformin acts as a bacterial chemorepellent, reducing bacterial penetration into mucus by altering motility and chemotaxis.

This paper uses deep learning to identify antibiotic modes of action from brightfield images without fluorescent labeling, achieving high accuracy in detecting drug exposure and novel mechanisms.

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

The paper analyzes Lgt homologues across bacterial pathogens to determine functional diversity and catalytic mechanisms, identifying a conserved motif and substrate specificity differences.

The paper introduces an automated framework for optimizing bacterial tracking pipelines using TrackMate 8, demonstrating its effectiveness on two use cases.

This paper investigates the morphological transformation of Helicobacter pylori from helical to coccoid form using microscopy techniques, revealing it occurs without a U-shaped intermediate and involves peptidoglycan thinning and membrane bulging.

This paper identifies HdpA's interaction with LhiA, a chaperone that regulates its activity, and shows how this complex controls peptidoglycan remodeling and shape transition in H. pylori.

This study identifies myocarditis and neutrophil-mediated vascular leakage as key factors in fatal murine leptospirosis, distinct from cytokine storm or organ failure.

The paper investigates the conformational switch of ExbD in the Ton system and its role in nutrient uptake, revealing the anchoring function of peptidoglycan and proposing a mechanistic model.

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.

This study shows that gut microbiota changes induced by chronic stress affect depressive-like behaviors and adult hippocampal neurogenesis through the endocannabinoid system in mice.

This study identifies the role of lytic transglycosylase LtgA in bacterial cell wall integrity and shows that targeting it can impair Neisseria meningitidis fitness during infection.