Mary C. Nakamura

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

The paper identifies gene signatures for human monocyte subsets using public transcriptomes, showing they accurately reflect subset levels in disease states and can be used for cytometry-based sorting.

This study shows that β-catenin signaling regulates chondrocyte-to-osteoblast transformation during fracture healing and identifies its role in stem cell generation for repair.