Author

Mehmet Akdag

Utrecht UniversityORCID 0000-0001-8170-6985Unclaimed ORCID profile · follow to get notified of new preprints

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

Tessa SinnigeiD· 2 shared Regina MenezesiD· 1 shared Sofia FerreiraiD· 1 shared Vera van SchijndeliD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersBiochemistry

Tessa SinnigeORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 1, 2025

Urolithin B reduces the aggregate load of islet amyloid polypeptide in Caenorhabditis elegans

Mehmet Akdag, Sofia Ferreira, Regina Menezes, Tessa Sinnige

This study shows urolithin B reduces insoluble IAPP-GFP levels in C. elegans without affecting mitochondrial association, suggesting a potential therapeutic strategy for T2DM.

DOI 10.1101/2025.07.01.662492

C. elegansproteomics

𝕏 PostBluesky

Cell BiologyBiophysical ChemistryPeer-reviewedJan 15, 2024

Islet amyloid polypeptide tagged with green fluorescent protein localises to mitochondria and forms filamentous aggregates in Caenorhabditis elegans

Mehmet Akdag, Vera van Schijndel, Tessa Sinnige

This study shows IAPP-GFP localizes to mitochondria and forms filamentous aggregates in C. elegans, suggesting potential as a tool for screening IAPP-solubilizing compounds for T2D therapy.

4 citations

C. elegansproteomics

𝕏 PostBluesky