Julien Duc

This study shows that ANTXR2 regulates COL6 turnover in skeletal muscle, and its deficiency leads to ECM stiffening and muscle dysfunction.

The paper shows ZNF93, a primate-specific protein, regulates APOBEC3B and influences cancer progression by affecting DNA synthesis and genomic stability.

This study identifies evolutionarily recent transcription factors that influence human cell cycle regulation by affecting gene expression and replication timing.

The paper identifies a noncanonical role for KZFPs in restricting TE-derived regulatory elements to maintain cell-type identity, independent of TRIM28.

This study shows that SCAN domain zinc-finger proteins bind transposon sequences and anchor nucleosomes, affecting chromatin structure and regulatory states.

The paper shows that a transposable element-derived domain in KRAB zinc-finger proteins enables new transcription factor functions through trimerization and condensate formation.

This study identifies ZNF274's role in anchoring lineage-specific gene clusters within repressive perinucleolar compartments, revealing its impact on chromatin structure and gene regulation.

The paper quantifies TE-mediated cis-regulation using statistical learning, showing TE-embedded CREs influence gene expression and can be predicted from RNA-seq data.

This study identifies POU5F1B as a human-specific oncoprotein that enhances cell invasiveness via plasma membrane remodeling through ubiquitination and S-acylation.

This study examines the genetic features and genomic targets of human KRAB-Zinc Finger Proteins, revealing their role in regulating transposable elements and their evolutionary significance.

This paper introduces TLC-CLIP, a method to profile RNA-protein interactions with increased sensitivity and efficiency by improving CLIP library preparation.

The paper identifies KZFP:TE transcriptional profiles and TE-derived promoters in the developing human brain, showing their role in neurogenesis.

This study identifies DPPA2 and DPPA4 as essential for activating Dux and LINE-1 transcription, which is critical for zygotic genome activation in mouse embryos.

The paper shows that the KZFP/KAP1 system dynamically regulates TEeRS in adult human T cells, affecting gene expression and chromatin states.