Iris Barshack

This paper uses multi-scale histology to identify localized age-related changes in normal human colon tissue using H&E images and machine learning.

This study shows that p53 inactivation promotes breast cancer brain metastasis by altering fatty acid metabolism, with implications for therapeutic targeting.

This paper introduces TIME_ACT, a transcriptomic signature predicting immune checkpoint blockade response across cancers, validated using histopathology and multiple cohorts.

This paper develops and tests Anti-4CB1, an anti-HVEM monoclonal antibody, showing enhanced anti-tumor activity in vitro and in vivo, particularly when combined with Anti-PD1, and correlates HVEM expression with treatment response.

This paper introduces a platform using amniotic fluid-derived organoids to model fetal development and study in utero pathologies in real-time.