Author

Tristan M. G. Kenney

University Health NetworkORCID 0000-0001-8242-4349Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

C.H. ArrowsmithiD· 2 shared Linda Z. PenniD· 2 shared A.M. EdwardsiD· 1 shared Ailing Pon· 1 shared Aiping DongiD· 1 shared Alma Seitova· 1 shared Andrew W. StamfordiD· 1 shared Anthony Joseph LambertoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

C.H. ArrowsmithORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMay 10, 2025

Structural basis of TMPRSS11D specificity and autocleavage activation

Bryan J. Fraser, Ryan P. Wilson, Sára Ferková…·C.H. Arrowsmith

The paper determines the structural basis of TMPRSS11D autocleavage activation and shows that nafamostat mesylate is cleaved by TMPRSS11D, reducing its efficacy as a protease inhibitor.

10 citations

humanstructural biology

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BiochemistryNature Chemical BiologyPeer-reviewedJul 4, 2024

Recruitment of FBXO22 for Targeted Degradation of NSD2

Yan Nie, John R. Tabor, Jianping Li…·C.H. Arrowsmith

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

73 citationstop 1%

humanexperimental assay

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