Birgit Mertens

This study develops a quantitative adverse outcome pathway for genotoxicity by modeling relationships between DNA alkylation and mutations/chromosome aberrations using existing data.

This paper develops a time-informed Adverse Outcome Pathway (AOP) network for environmental chemical-induced cardiotoxicity using data-driven methods and identifies key processes linking perturbations to cardiac injury.

The paper evaluates how different transcriptomic analysis workflows affect potency estimates in toxicogenomics, finding significant variability driven by normalization, filtering, and pathway definitions.

This study assesses the in vitro genotoxicity of Alternaria toxins using OECD-aligned assays, finding mutagenicity and chromosomal damage for several toxins.

This review analyzes variability and uncertainty in genotoxicity test guideline data, highlighting challenges in integrating non-animal methods into regulatory frameworks.