Author

Emmanuel Demuynck

Sciensano, Scientific Department of Chemical and Physical Health Risks;ORCID 0009-0003-1531-968XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Birgit MertensiD· 2 shared Anouck I. ThienpontiD· 1 shared Bob van de WateriD· 1 shared Carsten WeißiD· 1 shared Dayna R. SchultziD· 1 shared Dimosthenis Andreas SarigiannisiD· 1 shared Elisavet Renieri· 1 shared Freddy Van GoethemiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

Birgit MertensORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintNov 13, 2026

Advancing AOPs for genotoxicity through quantifying KERs linking DNA alkylation to increase in mutations and chromosome aberrations

Levi M.T. Winkelman, Emmanuel Demuynck, Steven M. Bryce…·Joost B. Beltman

This study develops a quantitative adverse outcome pathway for genotoxicity by modeling relationships between DNA alkylation and mutations/chromosome aberrations using existing data.

DOI 10.64898/2026.11.11.765894

humanbulk RNA-seq

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BioinformaticsToxicological SciencesPeer-reviewedSep 1, 2026

Analytical Choices Drive Toxicogenomic Potency Estimates: A Systematic Evaluation of Transcriptomic Points of Departure

Imke B. Bruns, Dayna R. Schultz, Emmanuel Demuynck…·Giulia Callegaro

The paper evaluates how different transcriptomic analysis workflows affect potency estimates in toxicogenomics, finding significant variability driven by normalization, filtering, and pathway definitions.

DOI 10.1093/toxsci/kfag115

humanbulk RNA-seq

𝕏 PostBluesky